Methotrexate and asthma.
نویسندگان
چکیده
population, 1)0th b()dV habitus and degree of effort expended in PEFR measurement var widely among patients. \Ve have found that percent predicted PEFRs are much more useful for the individual patient, both in assessing progress of therapy and in objectively comparing severity of respirator)’ distress with that on previous ED visits. Indeed, even the primary supporting study cited by the authors, that by Nowak et al,2 cautioned that patients with a body habitus falling outside the norm ma)’ benefit from percent predicted PEFR calculation. In summar ; the article 1w McNamara and Cionni, while suggesting an interesting use ofobjective data (PEFR), suffers somewhat from its lack of emphasis on other useful information that ma)’ he expeditiously obtained in the ED o)n patients in respirator)’ distress, namely, clinical and radiographic data. Patients with features of both CHF and CLD ma)’ he initially managed without a clear differentiatiom between the two. In addition, we have had good success with the routine use of percent predicted PEFRs in our ED, and we recommend their use in this setting.
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Despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. There are controversies about the role of methotrexate in lowering the need for corticosteroides in these patients. In this study an attempt has been made to determine methotrexate effects in corticosteroid dependent asthma. Six patients were entered in a ...
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1 Mullarkey MF, Lammert JK, Blumenstein BA. Long-term methotrexate treatment in corticosteroid dependent-asthma. Ann Intern Med 1990; 112:557-81 2 Shiner RJ, Nunn AJ, Chung KF, Ducan MG. Randomised, double blind, placebo controlled trial ofmethotrexate in steroid-dependent asthma. Lancet 1990; 336:137-40 3 Erzurum SC, Leff JA, Cochran JE, Ackerson LM, Szefler SJ, Martin RJ, et al. Lack of benef...
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ورودعنوان ژورنال:
- Chest
دوره 103 4 شماره
صفحات -
تاریخ انتشار 1993